Evaluation of IP3R3 Gene Silencing Effect on Pyruvate Dehydrogenase (PDH) Enzyme Activity in Breast Cancer Cells with and Without Estrogen Receptor
Background: Inositol 1,4,5-trisphosphate receptor (IP3R), a critical calcium ion (Ca2+) regulator, plays a vital role in breast michael harris sunglasses cancer (BC) metabolism.Dysregulated IP3R in BC cells can drive abnormal growth or cell death.Estradiol increases IP3R type 3 (IP3R3) levels in BC, promoting cell proliferation and metabolic change